20-HETE-d6 , ≥98% , 2548939-89-3

CAS NO.：2548939-89-3

Empirical Formula: C20H32O3

Molecular Weight: 320.47

MDL number: MFCD05863966

PRODUCT Properties

• solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 500 μg/ml
• form: Liquid
• color: Colorless to light yellow

Description and Uses

20-HETE-d₆ contains six deuterium atoms at the 16, 16', 17, 17', 18 and 18' positions. It is intended for use as an internal standard for the quantification of 20-HETE by GC- or LC-MS. 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature.¹ In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction.² 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.³