NapyradiomycinA1 , ≥98% , 103106-24-7
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB1824.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 642.5±55.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| form | A solid |
| pka | 6.14±0.70(Predicted) |
Description and Uses
Napyradiomycin A1 is a fungal metabolite originally isolated from C. rubra and has diverse biological activities. It is active against S. aureus, M. luteus, B. anthracis, C. bovis, and M. smegmatis (MICs = 1.56-12.5 μg/ml). Napyradiomycin A1 is an estrogen receptor antagonist (IC50 = 4.2 μM in rat uterine homogenates). It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM, respectively).
Napyradiomycin derivatives have antibacterial and tumor properties. Napyradiomycin A1 is a secondary metabolite isolated from Streptomyces. It is also an antibacterial antibiotic and an inhibitor of mitochondrial complexes I and II.
Safety
| HS Code | 29419000 |
| Toxicity | mouse,LD50,intraperitoneal,> 250mg/kg (250mg/kg),Journal of Antibiotics. Vol. 39, Pg. 487, 1986. |
