Bicalutamide-d4 , ≥98% , 1185035-71-5

CAS NO.：1185035-71-5

Empirical Formula: C18H10D4F4N2O4S

Molecular Weight: 434.4

MDL number: MFCD08063408

PRODUCT Properties

• Melting point: 192-1940C
• storage temp.: -20°C Freezer
• solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
• form: Solid
• color: White to Off-White

Description and Uses

Bicalutamide-d₄ is intended for use as an internal standard for the quantification of bicalutamide by GC- or LC-MS. Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (K_i = 12.5 μM; IC₅₀ = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.

BICALUTAMIDE-D4 is used as an antiandrogen, antineoplastic (hormonal). (94%d4; 5.7%d3, 0.1%d1, no d0