Purpurogallin , ≥95% , 569-77-7

CAS NO.：569-77-7

Empirical Formula: C11H8O5

Molecular Weight: 220.18

MDL number: MFCD00004145

EINECS: 209-324-9

PRODUCT Properties

• Melting point: 275 °C (dec.)(lit.)
• Boiling point: 321.11°C (rough estimate)
• Density: 1.3824 (rough estimate)
• refractive index: 1.5140 (estimate)
• storage temp.: −20°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 6.75±0.20(Predicted)
• color: Very Dark Brown
• Merck: 7946
• Stability: Air Sensitive
• LogP: 2.050 (est)

Description and Uses

Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties. It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and B. subtilis (MICs = 11-110 μg/ml), the Gram-negative bacteria S. marcescens, P. vulgaris, K. pneumoniae, E. coli, S. typhi, and E. cloacae (MIC = 110 μg/ml for all), as well as P. falciparum strain FCB1 clone NC-1 (IC₅₀ = 55 μM). Purpurogallin (2, 5, and 10 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay and reduces hydrogen peroxide- and radiation-induced production of reactive oxygen species (ROS) in HaCaT keratinocytes. It inhibits the activity of EGFR, glutathione-S-transferase (GST), prolyl endopeptidase, and glyoxalase I (IC₅₀s = 27.5, 8, 16, and 50 μM, respectively), as well as catechol O-methyltransferase (COMT; K_i = 0.074 μM), in cell-free assays.

xanthine oxidase inhibitor, antioxidant

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319-H315-H335
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DE8380000