Nodularin , ≥98% , 118399-22-7

Synonym(s):
1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Nodularin-R solution

CAS NO.：118399-22-7

Empirical Formula: C41H60N8O10

Molecular Weight: 824.96

MDL number: MFCD16659855

EINECS: 621-437-9

PRODUCT Properties

• Density: 1.29±0.1 g/cm3(Predicted)
• Flash point: 11℃
• storage temp.: −20°C
• solubility: methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
• form: Dry residue containing traces of monobasic potassium phosphate.
• pka: 3.39±0.70(Predicted)
• IARC: 3 (Vol. 94) 2010
• EPA Substance Registry System: Nodularin (118399-22-7)

Description and Uses

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC₅₀ of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.

Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H310+H330-H315-H317-H319-H335
• Precautionary statements: P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338
• Hazard Codes: T,F,T+
• Risk Statements: 23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28
• Safety Statements: 36/37-45-16-7-36/37/39-26
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: GU2294250
• Hazardous Substances Data: 118399-22-7(Hazardous Substances Data)
• Toxicity: mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993.