L-Leucyl-L-Leucinemethylester(hydrochloride) , ≥98% , 6491-83-4

CAS NO.：6491-83-4

Empirical Formula: C13H27ClN2O3

Molecular Weight: 294.818

MDL number:

PRODUCT Properties

• Melting point: 177-181°C
• storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
• solubility: DMSO (Slightly), Water (Slightly)
• form: Solid
• color: White to Off-White
• Stability: Hygroscopic

Description and Uses

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4⁺ and CD8⁺ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.

H-Leu-leu-OMe HCl