AvermectinB1a , 95% , 65195-55-3
CAS NO.：65195-55-3
Empirical Formula: C48H72O14
Molecular Weight: 873.09
MDL number: MFCD01769550
EINECS: 265-610-3
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1468.00 | In Stock |
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| 1mL*10mM(inDMSO) | RMB2448.00 | In Stock |
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| 10mg | RMB2548.00 | In Stock |
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| 25mg | RMB5236.00 | In Stock |
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| 50mg | RMB9028.00 | In Stock |
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| 100mg | RMB15508.00 | In Stock |
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| others | Enquire |
PRODUCT Properties
| Boiling point: | 940.9±65.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥143.4 mg/mL in DMSO; ≥11.86 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| form | Powder |
| pka | 12.42±0.70(Predicted) |
| color | White to light yellow |
| Stability: | Hygroscopic |
| EPA Substance Registry System | Avermectin B1a (65195-55-3) |
Description and Uses
Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent that binds to high and low affinity sites on the mammalian GABAA receptor. Binding to the high affinity site activates the receptor to increase chloride influx, while binding to the low affinity site blocks the channel. Avermectin B1a inhibits binding of the glycine receptor antagonist strychnine to membranes and the solubilized receptor from rat spinal cord (Kis = 1.3 and 3.6 μM, respectively). Formulations containing avermectin B1a (>80%) and avermectin B1b (~20%; ) are used in insecticides and veterinary anthelmintic formulas as abamectin .
Avermectin B1a is the major component (>80%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1a contains a secbutyl residue in the 25-position. In vitro and in vivo studies have shown that this analogue is the more potent analogue in the commercial product.
Safety
| Symbol(GHS) |    GHS08,GHS09,GHS06 |
| Signal word | Danger |
| Hazard statements | H330-H410-H300-H361d-H372 |
| Precautionary statements | P273-P391-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P260-P264-P270-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
| RIDADR | 2588 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | LD20 orl-rat: 10 mg/kg JAFCAU 32,94,84 |
