98% , 146510-36-3
CAS NO.：146510-36-3
Empirical Formula: C17H27Cl2N5
Molecular Weight: 372.34
MDL number: MFCD09837698
| Pack Size | Price | Stock | Quantity |
| 1g | RMB6400.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 454.7±55.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| pka | 11.92±0.10(Predicted) |
Description and Uses
In July 2015, olanexidine gluconate, a biguanide compound with remarkable antibacterial activity, was approved by the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan for skin antisepsis at surgical sites. The drug was developed and marketed by Otsuka Pharmaceutical in Japan and is available as topical solution (1.5%). Olanexidine gluconate exhibited efficacy against a wide range of bacterial strains, especially Grampositive bacteria. In vitro experiments exploring its mechanism of action indicated that olanexidine interacts with bacterial surface molecules (such as lipopolysaccharides and lipoteichoic acid), disrupting the cell membranes of liposomes. These models suggest that the drug permeates the membranes of both Escherichia coli and Staphylococcus aureus and denatures proteins at relatively high concentrations (>160 g/mL).
Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation[1][2][3].
