LN-937833
Ranimustine , 58994-96-0
CAS NO.：58994-96-0
Empirical Formula: C10H18ClN3O7
Molecular Weight: 327.72
MDL number: MFCD00866369
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 111-112° |
| alpha | D20 +93.2° (c = 0.5 in methanol) (Kimura); D25 +73.2° (c = 0.3 in methanol) (Kimura, Sekine) |
| Density | 1.69±0.1 g/cm3(Predicted) |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.59±0.46(Predicted) |
| color | Off-White to Pale Yellow |
Description and Uses
Ranimustine, a new nitrosourea derivative, is a water soluble antitumor agent with low hematological toxicity and diabetogenic effect. It is reportedly effective in the treatment of hematologic malignancies, especially the myeloproliferative disorders.
Glucocorticoid with low systemic absorption anti-inflammatory agent
Safety
| Toxicity | LD50 in male rats (mg/kg): 42 i.p., 42 i.v., 50 orally (Kimura) |
