Home Categories CAPREOMYCIN
LN-725392

CAPREOMYCIN , 99% , 11003-38-6

CAS NO.:11003-38-6

Empirical Formula: C50H88N28O15

Molecular Weight: 1321.41

MDL number: MFCD01770630

Update time: 2023-04-23

PRODUCT Properties

pka pKa in 66% aq DMF: 6.2, 8.2, 10.1, 13.3(at 25℃)

Description and Uses

Capreomycin is a semisynthetic antibiotic (34.1.21) that is isolated from the cultural fluid of Streptomyces capreolus, and it is a complex of a minimum of four microbiologically active ingredients that have only partially been characterized.
Capreomycin has a pronounced suppressive effect against Mycobacterium tuberculosis and Mycobacterium bovis. Most strains of Mycobacterium kansasii are also sensitive to kanamycin, while other, nontuberculous strains are not sensitive to it. It is often used upon necessity of using parenternal therapy through deep intramuscular injections. Capreomycin is less toxic than kanamycin and has somewhat more of a bacteriostatic effect. Synonyms of this drug are capromycin, capastat, ogostal, and others.

Capreomycin is a complex of cyclic pentopeptides isolated from Streptomyces capreolus, first reported in 1962. The complex has two major components, IA and IB, with an exocyclic lysine residue and two minor delysinyl components, IIA and IIB. Capreomycin is a potent antibiotic with activity against mycobateria, Gram positive and Gram negative organisms. Capreomycin acts by binding to the 23S ribosomal subunit, disrupting protein synthesis.

Safety

Hazardous Substances Data 11003-38-6(Hazardous Substances Data)

RELATED PRODUCTS