LN-626334
Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-diMethylethoxy)carbonyl]aMino]-3,5-dihydroxy-, (αS)- , 0.95 , 681282-72-4
Update time: 2023-04-23
PRODUCT Properties
Boiling point: | 534.7±35.0 °C(Predicted) |
Density | 1.406±0.06 g/cm3(Predicted) |
pka | 3.93±0.10(Predicted) |
Description and Uses
Boc-3,5-dihydroxy-1-adamantyl-L-glycine is a reactant in the synthesis of Saxagliptin (S143500), a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.