LN-580527
HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS , 29400-42-8
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 215° |
| alpha | D25 -121° (chloroform) |
| Boiling point: | 552.56°C (rough estimate) |
| Density | 1.1062 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMF:30.0(Max Conc. mg/mL);52.75(Max Conc. mM) DMSO:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) |
| form | A crystalline solid |
| pka | 4.05±0.41(Predicted) |
| color | White to off-white |
Description and Uses
Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.
Helvolic acid is a mycotoxin with antibacterial activity.
Safety
| RTECS | RC1370000 |
| HS Code | 29419000 |
