LN-430831
BREVETOXIN B , 95% , 79580-28-2
Synonym(s):
Brevetoxin B, GbTx-2;Brevetoxin PbTx-2, Ptychodiscus brevis - CAS 79580-28-2 - Calbiochem
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 270(Disassembly) |
| Density | 1.188±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Ethyl Acetate: soluble |
| form | A film |
| pka | 13.72±0.70(Predicted) |
| optical activity | +154.022 (CHCl3) |
Description and Uses
Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300+H310+H330 |
| Precautionary statements | P260-P262-P264-P280-P302+P352+P310-P304+P340+P310 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | XW5886000 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
