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Ivabradine
SDS-US
LN-225030

Ivabradine , 155974-00-8

CAS NO.：155974-00-8

Empirical Formula: C27H36N2O5

Molecular Weight: 468.59

MDL number: MFCD04975447

Update time: 2023-04-23

PRODUCT Properties

Boiling point: 626.9±55.0 °C(Predicted)
Density  1.146±0.06 g/cm3(Predicted)
pka 8.77±0.50(Predicted)

Description and Uses

Ivabradine is a first selective and specific If inhibitor that was approved by EMEA in November for symptomatic treatment of chronic stable angina pectoris in patients with normal sinus rhythm. This is the first agent to lower heart rate by inhibiting the cardiac pacemaker If current. The compound was discovered and developed by Servier and is currently being marketed in Ireland.

Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].

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