LN-060725
α-Amanitin , 85.0-99.8% , 11030-71-0
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 245 °C (decomp) |
Safety
| Toxicity | A drug derived from the highly poisonous fungus Amanita phalloides (death cap). Alpha-amanitin, a cyclic octapeptide, is toxic because of its affinity for RNA polymerase II in eukaryotic cells. Since this enzyme is responsible for mRNA synthesis in the cell, the compound is a potent and selective inhibitor of mRNA synthesis. It is effective at concentrations below 1 μg/mL, and its specific action has made it useful in experimental biology. It is often used with actinomycin D to block RNA synthesis. |