LN-029934
Domperidone Impurity 15 , 0.95 , 142799-22-2
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 66°C |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Water (Slightly, Heated, Sonicated) |
| form | Solid |
| color | White to Off-White |
Description and Uses
1,3-Bis(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one (~90%) is an intermediate in the synthesis of 3’-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]propyl Domperidine (Domperidine Impurity F) (C365315), an impurity of the gastrokinetic and antinauseant drug Domperidone (D531100(P)), which is a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.
