Dolutegravir Impurity 3 , 0.95 , 1973402-05-9

CAS NO.：1973402-05-9

Empirical Formula: C20H19F2N3O5

Molecular Weight: 419.38

MDL number:

PRODUCT Properties

• Melting point: 95-100°C
• Boiling point: 662.3±55.0 °C(Predicted)
• Density: 1.51±0.1 g/cm3(Predicted)
• storage temp.: -20°C Freezer, Under inert atmosphere
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 4.50±1.00(Predicted)
• color: Yellow

Description and Uses

(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.