LN-025533
Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN , 156192-32-4
Update time: 2023-04-23
PRODUCT Properties
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at 0-5°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 11.13±0.46(Predicted) |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. Protect from light! |
Description and Uses
Z-Leu-Arg-AMC (156192-32-4) is a sensitive Cathepsin K fluorogenic substrate (Km=8μM, kcat/Km=4 x 105 M-1s-1)1-3. It is cleaved more slowly by the following cathepsins (kcat/Km: B (105)4, F (106)4, L (106)4,5, L2/V (104)5, S (105)2,4,5. Also cleaved by malaria parasite proteases berghepain6, vivapain-2 and -37, and falcipain-1, -2, and -36,8,9. Excitation: 365nm, Emission: 440nm.
A sensitive fluorogenic substrate for cathepsin K
