NBI-42902 , NLT 98% , 352290-60-9

CAS NO.：352290-60-9

Empirical Formula: C27H24F3N3O3

Molecular Weight: 495.49

MDL number: MFCD20275092

Update time: 2023-04-23

PRODUCT Properties

form	Solid
color	White to off-white

Description and Uses

NBI-42902 is an orally active, potent functional and competitive antagonist of GnRH receptor with an IC50 value of 0.79 nM, a Ki value of 0.56 nM, respectively. NBI-42902 inhibits GnRH-stimulated inositol phosphate (IP) accumulation, Ca2+ flux, and ERK1/2 activation. NBI-42902 inhibits serum luteinizing hormone (LH) in castrated male macaques. NBI-42902 can be used for research on sex-hormone-related diseases[1].