Triethyl 4-phosphonocrotonate , Shunlian+transliteration, 94 , 10236-14-3

Synonym(s):
4-(Diethoxyphosphinyl)-2-butenoic acid ethyl ester;4-Phosphonocrotonic acid triethyl ester

CAS NO.：10236-14-3

Empirical Formula: C10H19O5P

Molecular Weight: 250.23

MDL number: MFCD00009192

PRODUCT Properties

• Boiling point: 135 °C0.4 mm Hg(lit.)
• Density: 1.128 g/mL at 25 °C(lit.)
• refractive index: n20/D 1.455(lit.)
• Flash point: >230 °F
• form: Liquid
• color: Clear light yellow

Description and Uses

Reactant for:

• Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase
• Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions
• Orally bioavailable GPR40 agonist synthesis
• Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
• Preaparation of mGlu4R agonists
• Dearomatizing cyclization of nicotinyl-substituted esters and ketones

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29319090