tert-Butyl1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate , 98% , 1446282-18-3

Synonym(s):
tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate;H₂N-PEG₅-CH₂CH₂COOtBu

CAS NO.：1446282-18-3

Empirical Formula: C17H35NO7

Molecular Weight: 365.46

MDL number: MFCD25424125

PRODUCT Properties

• Boiling point: 439.1±40.0 °C(Predicted)
• Density: 1.049±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in Water, DMSO, DCM, DMF
• pka: 8.74±0.10(Predicted)
• form: viscous liquid
• color: Light yellowish

Description and Uses

Amino-PEG5-t-butyl ester is a PEG molecule consisting of an amino group and a t-butyl protected carboxyl group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.The hydrophilic PEG spacer increases solubility in aqueous media.

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P280-P261
• HS Code: 2942000090