Rocaglamide , 98% , 84573-16-0

Synonym(s):
(1R,2R,3S,3aR,8bS)-2,3,3a,8b-Tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxamide;NSC 326408;Roc-A;Rocaglamide A

CAS NO.：84573-16-0

Empirical Formula: C29H31NO7

Molecular Weight: 505.56

MDL number: MFCD08702699

Pack Size	Price	Stock	Quantity
10mg	RMB6339.20	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Melting point:	117-118 °C
Boiling point:	667.3±55.0 °C(Predicted)
Density	1.321±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO or Ethanol
form	film
pka	11.70±0.70(Predicted)
color	colorless
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. Protect from exposure to light and moisture.

Description and Uses

Rocaglamide is an anti-inflammatory, insecticidal, and anticancer tetrahydrobenzofuran isolated from Aglaia species. It has been shown to inhibit both TNF-α and the activation of NF-κB in Jurkat T cells with IC₅₀ values in the nanomolar range. At 25 nM, rocaglamide induces apoptosis in various human leukemia cell lines, activating p38 MAPK/JNK and suppressing ERK. Rocaglamide also reduces IFN-γ, TNF-α, IL-2, and IL-4 production in peripheral blood T cells at a concentration of 50 nM. Furthermore, rocaglamide can inhibit the T cell expression of the immune response transcription factor, nuclear factor of activated T cells.

Rocaglamide is derived from a Chinese medicinal plant Aglaia. Rocaglamide induces apoptosis in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients.