Toltrazuril , 98% , 69004-03-1

Synonym(s):
1-Methyl-3-{3-methyl-4-[4-(trifluoromethylthio)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione;Baycox

CAS NO.：69004-03-1

Empirical Formula: C18H14F3N3O4S

Molecular Weight: 425.38

MDL number: MFCD00867201

EINECS: 614-893-5

PRODUCT Properties

• Melting point: 194-196°C
• Density: 1.54±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Toltrazuril is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of toltrazuril in ethanol is approximately 1 mg/ml and approximately 25 mg/ml in DMSO and DMF.
• pka: 6.47±0.20(Predicted)
• form: Solid
• color: White to off-white
• InChI: InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26)
• InChIKey: OCINXEZVIIVXFU-UHFFFAOYSA-N
• SMILES: N1(C)C(=O)NC(=O)N(C2=CC=C(OC3=CC=C(SC(F)(F)F)C=C3)C(C)=C2)C1=O

Description and Uses

Toltrazuril (Baycox®,Procox®) is a triazinon drug thathas broad-spectrum anticoccidial and antiprotozoalactivity. It is not commercially available in the UnitedStates, but it is available in other countries. It is activeagainst both asexual and sexual stages of coccidia byinhibiting nuclear division of schizonts and microga-monts and the wall-forming bodies of macrogamonts. Itmay also be useful in the treatment of neonatal porcinecoccidiosis, EPM, and canine hepatozoonosis.

Toltrazuril and its major metabolite ponazuril (toltrazuril sulfone, Marquis) are triazine-based antiprotozoal drugs that have specific activity against apicomplexan coccidial infections. Toltrazuril is not available within the United States.

Toltrazuril is an antiprotozoal agent that is widely used to prevent coccidia parasite infection in veterinary applications. The effectiveness of treatment appears to depend on the coccidian species, development stage of the parasite, and level of infection.

Safety

• Symbol(GHS): GHS09
• Signal word: Warning
• Hazard statements: H410
• Precautionary statements: P273-P391-P501
• Hazard Codes: N,Xi
• Risk Statements: 50/53-36/37/38
• Safety Statements: 60-61-37/39-26
• RIDADR: UN 3077
• WGK Germany: 2
• HS Code: 29336990