5'-O-(4,4'-Dimethoxytrityl)-N-isobutyryl-2'-deoxyguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite , 95% , 93183-15-4

Synonym(s):
DMT-dG(ib) amidite;DMT-dG(ib) Phosphoramidite;Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

CAS NO.：93183-15-4

Empirical Formula: C44H54N7O8P

Molecular Weight: 839.92

MDL number: MFCD00055147

EINECS: 685-519-6

PRODUCT Properties

• Density: 1.22 at 20℃
• vapor pressure: 0-0Pa at 20-50℃
• storage temp.: Sealed in dry,2-8°C
• solubility: soluble, clear
• form: powder or granules
• pka: 9.16±0.20(Predicted)
• color: white to off-white
• InChIKey: FDRMKYVTIFSDPR-MMROLVBFSA-N
• SMILES: C(OC[C@H]1O[C@@H](N2C=NC3C(=O)NC(NC(=O)C(C)C)=NC2=3)C[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C)(C1=CC=CC=C1)(C1=CC=C(OC)C=C1)C1=CC=C(OC)C=C1 |&1:3,5,23,r|
• LogP: 4.17 at 20℃

Description and Uses

2’-Deoxy-5’-O-DMT-N2-isobutyrylguanosine 3’-CE Phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319
• Precautionary statements: P264-P280-P305+P351+P338-P337+P313P
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29349990