Levocarnitine propionate hydrochloride , 96% , 119793-66-7
Synonym(s):
(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt;L -Carnitine propionyl ester;C3-Carnitine;Propanoyl-L -carnitine
CAS NO.:119793-66-7
Empirical Formula: C10H20ClNO4
Molecular Weight: 253.72
MDL number: MFCD00274137
EINECS: 922-939-3
Pack Size | Price | Stock | Quantity |
1g | RMB28.00 | In Stock |
|
5g | RMB84.00 | In Stock |
|
25g | RMB286.40 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 165-167°C |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | Chloroform (Slightly), Water (Slightly) |
form | Solid |
color | White to Off-White |
Stability: | Hygroscopic |
CAS DataBase Reference | 119793-66-7(CAS DataBase Reference) |
Description and Uses
Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids. Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; ) and 6-keto-prostaglandin F1α in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; ) in non-contaminated cells. It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal. Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.
L-Propionyl carnitine has been shown to improve the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
HS Code | 2923.90.0100 |