Levocarnitine propionate hydrochloride , 96% , 119793-66-7

Synonym(s):
(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt;L-Carnitine propionyl ester;C3-Carnitine;Propanoyl-L-carnitine

CAS NO.：119793-66-7

Empirical Formula: C10H20ClNO4

Molecular Weight: 253.72

MDL number: MFCD00274137

EINECS: 922-939-3

PRODUCT Properties

• Melting point: 165-167°C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Chloroform (Slightly), Water (Slightly)
• form: Solid
• color: White to Off-White
• Stability: Hygroscopic

Description and Uses

Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids. Propionyl-L-carnitine increases the basal release of prostaglandin E₂ (PGE₂; ) and 6-keto-prostaglandin F_1α in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B₂ (TXB₂; ) in non-contaminated cells. It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal. Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.

L-Propionyl carnitine has been shown to improve the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• HS Code: 2923.90.0100