11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride , 95% , 111974-74-4

CAS NO.：111974-74-4

Empirical Formula: C17H19Cl2N3S

Molecular Weight: 368.324

MDL number: MFCD08703302

EINECS: 1312995-182-4

PRODUCT Properties

• Melting point: 180-184°C
• storage temp.: Inert atmosphere,2-8°C
• solubility: Soluble in DMSO, Methanol, Distilled Water
• form: solid
• color: Off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
• InChI: InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H
• InChIKey: MJPARFLICDXWJT-UHFFFAOYSA-N
• SMILES: C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl
• CAS DataBase Reference: 111974-74-4(CAS DataBase Reference)

Description and Uses

Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic

Safety

• Symbol(GHS): GHS06
• Signal word: Warning
• Hazard statements: H413
• Precautionary statements: P501-P273
• HS Code: 2934990002