β-Lapachone , 98% , 4707-32-8

CAS NO.：4707-32-8

Empirical Formula: C15H14O3

Molecular Weight: 242.27

MDL number: MFCD01712233

PRODUCT Properties

• Melting point: >110°C (dec.)
• Boiling point: 381.4±42.0 °C(Predicted)
• Density: 1.25±0.1 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
• form: Orange to brown solid.
• color: Orange
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code
• InChIKey: QZPQTZZNNJUOLS-UHFFFAOYSA-N
• LogP: 2.820 (est)

Description and Uses

β-Lapachone (4707-32-8) is a naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1?Induces apoptosis in a number of cancer cell lines.2?In cancer cells over-expressing NAD(P)H:quinone oxidoreductase, reduction of β-lapachone leads to futile cycling between quinone and hydroquinone forms3?resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFκB.5

β-Lapachone has been used:

• as an anticancer compound in catalase-inhibitable luminol/hydrogen peroxide (HRP)-dependent chemiluminometric?assay in Lewis lung carcinoma (LLC) cells and isolated mitochondria
• as a naphthoquinone to study its effects on the growth and differentiation of mice granulocyte and macrophage progenitor cells
• as a substrate to study the enzyme activity of human recombinant NAD(P)H dehydrogenase 1 (NQO1) protein

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3
• RTECS: QL6127400
• HS Code: 2932990090