Fenbufen , 99% , 36330-85-5

Synonym(s):
γ-Oxo-(1,1′-biphenyl)-4-butanoic acid

CAS NO.：36330-85-5

Empirical Formula: C16H14O3

Molecular Weight: 254.29

MDL number: MFCD00056701

EINECS: 252-979-0

PRODUCT Properties

• Melting point: 184-187 °C (lit.)
• Boiling point: 357.5°C (rough estimate)
• Density: 1.1565 (rough estimate)
• refractive index: 1.5600 (estimate)
• storage temp.: 2-8°C
• solubility: Very slightly soluble in water, slightly soluble in acetone, in ethanol (96 per cent) and in methylene chloride.
• pka: pKa 4.3(H2O tunde?ned Iunde?ned) (Uncertain)
• form: Solid
• color: White to off-white
• Water Solubility: 2.212mg/L(25 ºC)
• Merck: 13,3990
• EPA Substance Registry System: [1,1'-Biphenyl]-4-butanoic acid, .gamma.-oxo- (36330-85-5)

Description and Uses

Fenbufen has been found to be an effective, well-tolerated drug for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Fenbufen is prepared by the Friedel-Crafts (aluminum chloride – nitrobenzene) acylation of biphenyl with succinic anhydride. The compound is metabolized in humans first to 4-hydroxy-4-biphenylbutyric acid (tmax 2.5 h) then to 4-biphenyl acetic acid (tmax 7.5 h). Both metabolites are more active than fenbufen itself and circulate for several hours (t1/2 10 h). This slow conversion of fenbufen to active metabolites having relatively long plasma half-lives allows for once a day dosing with this agent.

muscle relaxant (smooth)

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310+P330
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 28-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: DV1761000
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 2918300090
• Toxicity: LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte)