2-Nitro-1-naphthol , 98% , 607-24-9

CAS NO.：607-24-9

Empirical Formula: C10H7NO3

Molecular Weight: 189.17

MDL number: MFCD00003956

EINECS: 210-131-7

PRODUCT Properties

• Melting point: 123-125 °C (lit.)
• Boiling point: 324.41°C (rough estimate)
• Density: 1.3175 (rough estimate)
• refractive index: 1.5400 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• pka: 6.13±0.50(Predicted)
• form: Powder
• InChI: InChI=1S/C10H7NO3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H
• InChIKey: MUCCHGOWMZTLHK-UHFFFAOYSA-N
• SMILES: C1(O)=C2C(C=CC=C2)=CC=C1[N+]([O-])=O

Description and Uses

2-Nitro-1-naphthol is an important organic compound with anti-inflammatory properties used as an analytical method for measuring albumin concentration and as an enzyme-labelled substrate in electrochemical immunoassays. The substance reacts with albumin to form a coloured complex which can be detected spectrophotometrically. It is also used as a model system for the study of inflammatory diseases and inhibits p38 kinase activity. In addition, a derivative of 2-Nitro-1-naphthol (4-nitro-1-naphthol) can be used to prepare chromogenic substrates for neutral or slightly acidic hydrolases.

2-Nitro-1-naphthol was employed as substrate for use in an amperometric 3-electrode system for the determination of alkaline phosphatase, the enzyme label most commonly used in electrochemical immunoassays. It was also used in the preparation of:

• di-(2-nitro-1-naphthyl) hydrogen phosphate
• 1-(2′-methyl-3′-indenyl)-2-naphthylamine and -2-naphthol (axially chiral ligands)

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39-24/25-36
• WGK Germany: 3
• Hazard Note: Irritant
• HS Code: 29089990