N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine , 98% , 1892-57-5

Synonym(s):
N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide;EDC;WSC

CAS NO.：1892-57-5

Empirical Formula: C8H17N3

Molecular Weight: 155.24

MDL number: MFCD00044916

EINECS: 217-579-2

PRODUCT Properties

• Boiling point: 66-68°C/1mm
• Density: 0.877 g/mL at 20 °C (lit.)
• refractive index: n20/D 1.461
• Flash point: 66-68°C/1mm
• storage temp.: -20°C
• solubility: Chloroform
• pka: 9.52±0.28(Predicted)
• form: Liquid
• Specific Gravity: 0.885
• color: Colorless to slightly yellow
• Water Solubility: Soluble in water.
• Sensitive: Air Sensitive
• BRN: 507429
• InChIKey: LMDZBCPBFSXMTL-UHFFFAOYSA-N
• CAS DataBase Reference: 1892-57-5(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5)
• EPA Substance Registry System: 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5)

Description and Uses

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is a water-soluble carbodiimide available as hydrochloride salt. This compound is a carboxyl- and amine-reactive crosslinker that is water soluble and can activate carboxyl residues for their reaction with primary amines to form O-acylisourea as a reaction intermediate, which reacts with amide bonds to release isourea as a by-product. It can crosslink the carboxy-group of glutamate and aspartate to the side-chain primary amine of lysine and the amino group at the N-terminus. The crosslinker readily reacts at a pH range of 4.5–7.2 and only crosslinks the residues within their van der Waals distance. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is also widely used in fabricating different nanosystems implemented in drug/protein delivery systems. It is mainly used for surface crosslinking/immobilization of drugs to increase stability against environmental changes, such as pH or temperature[1-2].

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

Safety

• Symbol(GHS): GHS06,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H302-H311-H315-H317-H373-H410
• Precautionary statements: P260-P273-P280-P301+P312-P302+P352+P312-P314
• Hazard Codes: C
• Risk Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• F: 1-3-10
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• HS Code: 29252900