Tetrahydroberberine , 98+% , 522-97-4

CAS NO.：522-97-4

Empirical Formula: C20H21NO4

Molecular Weight: 339.39

MDL number: MFCD00067284

EINECS: 208-338-2

PRODUCT Properties

• Melting point: 166.5 °C
• Boiling point: 476.1±45.0 °C(Predicted)
• Density: 1.33±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO: >10 mg/mL, soluble
• form: solid
• pka: 6.53±0.20(Predicted)
• color: yellow

Description and Uses

Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P330-P501
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• Toxicity: LD50 in mice (mg/kg): 940 orally; 790 s.c.; 100 i.v. (Sadritdinov, Sultanov)