Ingenol , 99+% , 30220-46-3

CAS NO.：30220-46-3

Empirical Formula: C20H28O5

Molecular Weight: 348.43

MDL number: MFCD00056380

PRODUCT Properties

• Melting point: 153 °C
• Boiling point: 523.8±50.0 °C(Predicted)
• Density: 1.33±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO: soluble
• form: film
• pka: 12.06±0.70(Predicted)
• color: colorless

Description and Uses

Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. It is a protein kinase C activator that displays a K_i value of 30 μM and an ED₅₀ value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.

Ingenol, is the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis.

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H315-H318
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 38-41
• Safety Statements: 26-36
• WGK Germany: 3
• HS Code: 2914409000