tert-Butyl1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate , 95% , 1286281-32-0

Synonym(s):
tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate;H₂N-PEG6-CH₂CH₂COOtBu

CAS NO.：1286281-32-0

Empirical Formula: C19H39NO8

Molecular Weight: 409.51

MDL number: MFCD13184944

PRODUCT Properties

• Boiling point: 475.9±40.0 °C(Predicted)
• Density: 1.056±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• form: Oil
• pka: 8.74±0.10(Predicted)
• color: Colorless to light yellow

Description and Uses

Amino-PEG6-t-butyl ester is a PEG reagent containing an amino NH2 group with a t-butyl protected carboxyl group (Boc). The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• HS Code: 2942000090