Home Categories Biochemical Engineering IbutilideFumarate
BD4883441

IbutilideFumarate , 98% , 122647-32-9

Synonym(s):
(±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide hemifumarate salt;Corvert;Ibutilide hemifumarate salt

CAS NO.:122647-32-9

Empirical Formula: (C20H36N2O3S)2.C4H4O4

Molecular Weight: 885.24

MDL number: MFCD01715410

EINECS: 687-381-2

Pack Size Price Stock Quantity
100mg RMB572.00 In Stock
250mg RMB857.60 In Stock
1g RMB2144.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 112-117?C
RTECS  PB0475700
storage temp.  2-8°C
solubility  H2O: >20mg/mL
form  solid
color  off-white to tan
λmax 267nm(EtOH)(lit.)
Merck  14,4883
CAS DataBase Reference 122647-32-9(CAS DataBase Reference)

Description and Uses

Covert was launched in the US and UK for treatment of atrial fibrillation and flutter and can be synthesized in three steps from N-phenyl rnethanesulfonamide. While ibutilide has an asymmetric center, it has been determined that the racemate is equipotent with either enantiomer. The antiarrhythmic action is derived from the compounds ability to prolong the action potential duration and lengthen the refractory period of myocardial tissue. Class Ⅲ antiarrhythrnic agents accomplish this by blocking outward potassium channels, however, ibutilide elicits the same effect by activation of slow inward sodium channels. Recent evidence indicates that it also is a potent blocker of the rapidly acting delayed rectifier potassium current (lkr)and may block the ATP-inhibited potassium channel.

A methanesulfonanilide antiarrhythmic agent; prologns myocardial action potential duration, predominantly by activation of slow inward sodium current. Antiarrhythmic (class III).

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361d
Precautionary statements  P202-P264-P270-P280-P301+P312-P308+P313
Hazard Codes  Xn
Risk Statements  22
WGK Germany  1
HS Code  2935904000
Toxicity rat,LD,oral,> 500mg/kg (500mg/kg),Teratology, The International Journal of Abnormal Development. Vol. 49, Pg. 406, 1994.

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