6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide1,1-Dioxide , 98%+(mixtureofisomers) , 2259-96-3

Synonym(s):
6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide

CAS NO.：2259-96-3

Empirical Formula: C14H16ClN3O4S2

Molecular Weight: 389.88

MDL number: MFCD00210192

EINECS: 218-859-7

PRODUCT Properties

• Melting point: 234°
• Density: 1.3781 (rough estimate)
• refractive index: 1.6100 (estimate)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 9 mg/ml)
• pka: pKa 9.1(30% EtOH) (Uncertain)
• form: White to off-white solid.
• color: Off-white
• λmax: 273nm(lit.)
• Merck: 14,2754
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• EPA Substance Registry System: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide (2259-96-3)

Description and Uses

Cyclothiazide (2259-96-3) is a positive allosteric modulator of AMPA receptors acting at a site distinct from that of 2,3-benzodiazepines.1,2 Clinically useful diuretic and antihypertensive agent.3 Induces robust epileptiform activity, inducing seizures but without neuronal death.4,5 Can be used to produce a new animal model for epilepsy.5

Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H335-H319-H315
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: DK9610000
• HS Code: 2935904000
• Hazardous Substances Data: 2259-96-3(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: > 5gm/kg