Salsalate , 98% , 552-94-3

Synonym(s):
Salsalate;salicylsalicylic acid;2-(2-Hydroxybenzoyl)oxybenzoic acid;2-Hydroxybenzoic acid 2-carboxyphenyl ester;disalicylic acid

CAS NO.：552-94-3

Empirical Formula: C14H10O5

Molecular Weight: 258.23

MDL number: MFCD00020252

EINECS: 209-027-4

PRODUCT Properties

• Melting point: 139-151 °C
• Boiling point: 361.48°C (rough estimate)
• Density: 1.3326 (rough estimate)
• refractive index: 1.4825 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: ≥15mg/mL
• pka: pKa 3.5 (Uncertain);9.8 (Uncertain)
• form: Crystalline Powder
• color: white to tan
• Water Solubility: HYDROLYSIS
• Sensitive: Moisture Sensitive
• Merck: 14,8339

Description and Uses

Salsalate, or salicylsalicylic acid, (pKa 3.5 [COOH], 9.8 [AR-OH]) is a dimer of salicylic acid. It is insoluble in gastric juice but is soluble in the small intestine, where it is partially hydrolyzed to two molecules of salicylic acid and absorbed. On a molar basis, it produces 15% less salicylic acid than aspirin. It does not cause GI blood loss and can be given to aspirin-sensitive patients. Salsalate is available as capsules and tablets.

Nonacetylated (e.g., sodium salicylate) and acetylated (aspirin) forms of salicylate are widely used to target inflammation in the treatment of insulin resistance, type 2 diabetes, or rheumatic pain. Sasapyrine is a dimeric prodrug comprising two esterified salicylate moieties. It is advantageous over sodium salicylate because it is insoluble at the acid pH of the stomach and passes suspended but undissolved into the small intestine, sparing the gastric mucosa direct contact.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H302-H400
• Precautionary statements: P264-P270-P273-P301+P312-P391-P501
• Hazard Codes: Xi,N,Xn
• Risk Statements: 36/37/38-50-22
• Safety Statements: 37/39-26-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: DH2080000
• TSCA: Yes
• HS Code: 29182300