BD3648245
N-(2,6-Dimethylphenyl)-2-(hexahydro-1H-pyrrolizin-7a-yl)acetamidehydrochloride , 97% , 88069-49-2
Synonym(s):
N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide hydrochloride;Pilzicainide hydrochloride;SUN 1165
| Pack Size | Price | Stock | Quantity |
| 1g | RMB1548.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 212-214° |
| storage temp. | room temp |
| solubility | Chloroform (Slightly), Water (Slightly) |
| form | powder |
| color | white to beige |
Description and Uses
Pilsicainide hydrochloride is a new pynolizidine lidocaine derivative with antiarrhythmic activity. It is the first pharmaceutical product introduced by Suntory and was solely developed in Japan. The compound is reported to be highly effective in the treatment of premature ventricular contraction. It has no anticholinergic or CNS activity and is not as likely as other class 1C antiarrhythmics to have restricted indications.
Pilsicainide hydrochloride has been used as a sodium channel blocker:
- to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
- to study its effects on Ca2+?release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
- to study its electrophysiological effects on the guinea pig atrium
Safety
| Symbol(GHS) |  GHS06 |
| Symbol(GHS) | GHS06 |
| Signal word | Danger |
| Signal word | Danger |
| Hazard statements | H301 |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 2933.99.7000 |
| Toxicity | LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985) |
