Sodium(S)-2-hydroxypentanedioate , 95% , 63512-50-5
Synonym(s):
(S)-2-Hydroxypentanedioic acid disodium salt;Disodium (S)-2-hydroxyglutarate
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB120.00 | In Stock |
|
| 1g | RMB330.40 | In Stock |
|
| 5g | RMB1072.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >300°C |
| storage temp. | 2-8°C |
| solubility | Methanol (Very Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH |
| BRN | 5318042 |
Description and Uses
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.
L-α-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 α (HIF-1α), a marker of hypoxia in human tumors. It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.
Safety
| WGK Germany | 3 |
