Ah6809 , 98% , 33458-93-4

Synonym(s):
6-Isopropoxy-9-oxoxanthene-2-carboxylic acid

CAS NO.：33458-93-4

Empirical Formula: C17H14O5

Molecular Weight: 298.29

MDL number: MFCD08056083

PRODUCT Properties

• storage temp.: Sealed in dry,Room Temperature
• solubility: ethanol: 2.5 mg/mL, soluble
• form: crystalline solid or supercooled liquid
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.

Description and Uses

AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP₁, EP₂, EP₃-III, and DP₁ receptors. AH 6809 blocks the PGE₂-induced accumulation of cAMP in COS cells transfected with the human EP₂ receptor. It also blocks the accumulation of Ca²⁺ in Xenopus oocytes expressing the human EP₁ receptor. In the human and guinea pig, the activity profile of AH 6809 is similar to that of SC-19220, but it is somewhat more potent. In the mouse, AH 6809 has the highest affinity for the EP₂ receptor, but also acts as a weak ligand at the murine EP₁ and DP₁ receptors. In whole human platelets, AH 6809 is an effective antagonist of the antiaggregatory actions of PGD₂, but not PGI₂, with an EC₅₀ of about 5 x 10⁻⁵ M.

AH-6809 is a prostaglandin E2 receptor antagonist.

Safety

• WGK Germany: 3