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BD3248645

FoscarnetSodium , 97% , 63585-09-1

Synonym(s):
Foscarnet;Foscarnet sodium hexahydrate;Phosphonoformic acid trisodium salt hexahydrate;Sodium phosphonoformate tribasic hexahydrate

CAS NO.:63585-09-1

Empirical Formula: CNa3O5P

Molecular Weight: 191.95

MDL number: MFCD00013973

EINECS: 695-653-7

Pack Size Price Stock Quantity
5g RMB25.60 In Stock
25g RMB85.60 In Stock
100g RMB280.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >250°
storage temp.  Inert atmosphere,Room Temperature
form  Solid
color  White to off-white
Water Solubility  ≥ 24.9mg/mL in water
CAS DataBase Reference 63585-09-1(CAS DataBase Reference)

Description and Uses

Foscamet sodium is a new, injectable antiviral agent useful in the treatment of severe cytomegalovirus retinitis in immunodepressed patients. Foscarnet sodium acts by inhibiting viral-specific DNA polymerases; its side-effects include decreased hemoglobin levels and acute tubular necrosis.

Inhibits viral DNA polymerase and reverse transcriptase.
Foscarnet is the only antiviral approved by the FDA for the treatment of acyclovir-resistant HSV infections, a growing problem in the AIDS population. Foscarnet does not require HSV-encoded thymidine kinase. Foscarnet therapy reduces the healing time, pain, and viral shedding. It is administered intravenously, 40 mg/kg every 8 to 12 hours within 7 to 10 days in patients suspected of having acyclovir-resistant herpes simplex infection. Foscarnet is administered for 10 days. Associated side effects include azotemia secondary to nephrotoxicity, hyperphosphatemia, hypocalcemia, anemia, nausea, vomiting, and genital ulceration. Patients may eventually develop resistant strains. Preliminary trials indicate that topical 1%foscarnet cream may have some benefit for the treatment of acyclovir-resistant mucocutaneous HSV infection in patients with AIDS.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Toxicity LD50 i.p. in mice: 2000-4000 mmol/kg (Eriksson)

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