(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone , 97% , 77943-39-6

Synonym(s):
(4R,5S)-4-Methyl-5-phenyl-2-oxazolidinone

CAS NO.：77943-39-6

Empirical Formula: C10H11NO2

Molecular Weight: 177.2

MDL number: MFCD00010845

PRODUCT Properties

• Melting point: 121-123 °C(lit.)
• Boiling point: 309.12°C (rough estimate)
• Density: 1.1607 (rough estimate)
• refractive index: 1.5168 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• form: Liquid
• pka: 12.35±0.60(Predicted)
• color: Clear colorless to yellow-brown, may darken in storage
• optical activity: [α]18/D +168°, c = 2 in chloroform
• BRN: 1211705
• InChI: InChI=1S/C10H11NO2/c1-7-9(13-10(12)11-7)8-5-3-2-4-6-8/h2-7,9H,1H3,(H,11,12)/t7-,9-/m1/s1
• InChIKey: PPIBJOQGAJBQDF-VXNVDRBHSA-N
• SMILES: O1[C@@H](C2=CC=CC=C2)[C@@H](C)NC1=O
• CAS DataBase Reference: 77943-39-6(CAS DataBase Reference)

Description and Uses

Evan′s chiral auxiliary (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone reacts with carboxylic acids to produce corresponding acyl derivatives in the presence of a diisopropylcarbodiimide reagent. It can also employed in the preparation of N-sulfinyloxazolidinone reagent (chiral sulfinyl transfer reagent), which reacts with nucleophiles such as Grignard reagents, enolates, and metalated amides to produce the chiral sulfoxides, sulfinate esters, and sulfonamides.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: N
• Safety Statements: 22-24/25
• WGK Germany: 3
• HS Code: 29349990