PRODUCT Properties
| Density | 1.298 |
| storage temp. | 2-8°C |
| solubility | ≤1mg/ml in DMSO |
| form | crystalline solid |
| pka | pK1: 2.40;pK2: 3.70;pK3: 9.20 (25°C) |
| color | White to off-white |
Description and Uses
L-Canaline is an aminooxy analog of ornithine that irreversibly inhibits aminotransferases (transaminases), including ornithine aminotransferase (Ki = 2 μM). It forms oximes with α-keto acids and aldehydes, most notably with pyridoxal phosphate, an essential cofactor of aminotransferases. L-Canaline is naturally found in plants, including legumes, and is involved in the metabolism of L-canavanine, an aminooxy analog of arginine. It is cytotoxic to a range of organisms, including bacteria, insects, and parasites.
Safety
| Symbol(GHS) |   GHS07,GHS05 |
| Signal word | Danger |
| Hazard statements | H332-H302-H312-H335-H315-H318 |
| Precautionary statements | P261-P271-P304+P340-P312-P280-P305+P351+P338-P310-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
| Safety Statements | 22-24/25 |
