PRODUCT Properties
| Melting point: | 144-148 °C(lit.) |
| Boiling point: | 243.3 °C (0.3 mmHg) |
| Density | 1.1404 (rough estimate) |
| refractive index | 1.6600 (estimate) |
| Flash point: | 208 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Very slightly soluble in water; slightly soluble in ethanol (96%) and in ether. Solutions are yellow to red. |
| form | powder to crystal |
| pka | pKa 4.09(H2O,t =25,I=0.1) (Uncertain) |
| color | White to Light yellow |
| Merck | 14,7234 |
Description and Uses
Phenindione is an anticoagulant and vitamin K antagonist. It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates in a concentration-dependent manner. In vivo, phenindione (500 mg/kg) inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively. Dietary administration of phenindione (4 mg/kg per day) inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively.
Oral anticoagulant (indanedione).
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301-H317 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazard Codes | T |
| Risk Statements | 25-43 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | NK6125000 |
| HS Code | 2914.39.9000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
