Isoginkgetin , 95% , 548-19-6
Synonym(s):
8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one;Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB755.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 355℃ |
| Boiling point: | 843.6±65.0 °C(Predicted) |
| Density | 1.506 |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml |
| form | powder |
| pka | 6.16±0.40(Predicted) |
| color | White-beige |
| InChIKey | HUOOMAOYXQFIDQ-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(OC)C=C2)OC2=C(C3=CC(C4OC5=CC(O)=CC(O)=C5C(=O)C=4)=CC=C3OC)C(O)=CC(O)=C2C(=O)C=1 |
| LogP | 5.240 (est) |
Description and Uses
Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing. Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; ) and LPS by approximately 87 and 90%, respectively. It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; ) and the calcium ionophore A23187 by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM. Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.
