Icatibant , 98% , 130308-48-4

Synonym(s):
;Icatibant acetate

CAS NO.：130308-48-4

Empirical Formula: C59H89N19O13S

Molecular Weight: 1304.52

MDL number: MFCD00213940

PRODUCT Properties

• Density: 1.60±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM)
• form: powder
• pka: 3.60±0.21(Predicted)
• color: white
• Water Solubility: Soluble to 1 mg/ml in water
• Sequence: H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
• InChIKey: QASONHYHOCRAHL-DOMVFXHKSA-N
• CAS DataBase Reference: 130308-48-4

Description and Uses

Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].

Antagonist (bradykinin).

Safety

• WGK Germany: 3