(S)-2-Amino-5-((4-nitrophenyl)amino)-5-oxopentanoicacidhydrochloride , 97% , 67953-08-6
Synonym(s):
L -γ-Glutamyl-p-nitroanilide
CAS NO.：67953-08-6
Empirical Formula: C11H14ClN3O5
Molecular Weight: 303.7
MDL number: MFCD00039054
EINECS: 267-944-5
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB304.80 | In Stock |
|
| 25mg | RMB716.80 | In Stock |
|
| 50mg | RMB1219.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | 2-8°C |
| solubility | Soluble in Water (up to 5 mg/ml). |
| form | solid |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month. |
Description and Uses
L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3
L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
