Sofalcone , 97% , 64506-49-6
CAS NO.：64506-49-6
Empirical Formula: C27H30O6
Molecular Weight: 450.52
MDL number: MFCD00868207
EINECS: 1308068-626-2
| Pack Size | Price | Stock | Quantity |
| 1g | RMB49.60 | In Stock |
|
| 5g | RMB148.00 | In Stock |
|
| 10g | RMB250.40 | In Stock |
|
| 25g | RMB504.80 | In Stock |
|
| 100g | RMB1524.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 143-144° |
| Boiling point: | 478.6°C (rough estimate) |
| Density | 1.1362 (rough estimate) |
| refractive index | 1.4870 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 2.98±0.10(Predicted) |
| color | Light Yellow |
| CAS DataBase Reference | 64506-49-6(CAS DataBase Reference) |
Description and Uses
Sofalcone is a synthetic antiulcer agent related to sophoradin, the active principle of the Chinese medicinal plant, Sophora subprostata. It is suggested to act via a strengthening of the mucosal barrier through an increase in blood flow and stimulation of the synthesis of sulfated mucopolysaccharides.
Sofalcone is an anti-ulcer chalcone derivative. It blocks inflammation by suppressing the production of nitric oxide, TNF-α, and MCP-1 while inducing the expression of heme oxygenase-1 when used at 10-20 μM. Sofalcone (20-50 μM) induces VEGF expression in gastric epithelial cells and promotes gastric ulcer healing following eradication therapy for H. pylori.[Cayman Chemical]
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Toxicity | LD50 in mice, rats: >10 g/kg orally (Tarumoto) |
