BD1193232
2-Chloro-2,2-difluoro-1-phenylethanone , 98% , 384-67-8
Synonym(s):
α-Chloro-α,α-difluoroacetophenone;2-Chloro-2,2-difluoro-1-phenylethanone;Chlorodifluoromethyl phenyl ketone
CAS NO.:384-67-8
Empirical Formula: C8H5ClF2O
Molecular Weight: 190.57
MDL number: MFCD00042123
EINECS: 621-031-1
Pack Size | Price | Stock | Quantity |
5g | RMB3174.40 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 102-103 °C |
Boiling point: | 94-96 °C35 mm Hg(lit.) |
Density | 1.293 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 163 °F |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | Difficult to mix. |
form | liquid |
color | Clear, colourless |
BRN | 2251448 |
CAS DataBase Reference | 384-67-8(CAS DataBase Reference) |
Description and Uses
Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.
2-Chloro-2,2-difluoroacetophenone can be used:
- As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
- As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
- As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36-37 |
RIDADR | UN 3334 |
WGK Germany | 3 |
F | 19 |
Hazard Note | Irritant |
HS Code | 29147000 |