BD1193232
2-Chloro-2,2-difluoro-1-phenylethanone , 98% , 384-67-8
Synonym(s):
α-Chloro-α,α-difluoroacetophenone;2-Chloro-2,2-difluoro-1-phenylethanone;Chlorodifluoromethyl phenyl ketone
CAS NO.：384-67-8
Empirical Formula: C8H5ClF2O
Molecular Weight: 190.57
MDL number: MFCD00042123
EINECS: 621-031-1
| Pack Size | Price | Stock | Quantity |
| 5g | RMB3174.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 102-103 °C |
| Boiling point: | 94-96 °C35 mm Hg(lit.) |
| Density | 1.293 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 163 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Difficult to mix. |
| form | liquid |
| color | Clear, colourless |
| BRN | 2251448 |
Description and Uses
Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.
2-Chloro-2,2-difluoroacetophenone can be used:
- As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
- As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
- As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37 |
| RIDADR | UN 3334 |
| WGK Germany | 3 |
| F | 19 |
| Hazard Note | Irritant |
| HS Code | 29147000 |
