PRODUCT Properties
| Melting point: | 173-174°C |
| Boiling point: | 257.07°C (rough estimate) |
| Density | 1.3037 (rough estimate) |
| refractive index | 1.5090 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pK (25°) 3.90 |
| color | White to Pale Gray |
| Water Solubility | Soluble in water, dimethyl sulfoxide or 100% ethanol. |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 480-64-8 |
Description and Uses
Orsellinic acid is a fungal metabolite and benzoic acid derivative with antioxidant and neuroprotective activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals with an IC50 value of 5 mM. Orsellinic acid (1 μg/ml) prevents PARP cleavage induced by platelet-activating factor (PAF) in PC12-AC cells and PAF-induced cytotoxicity in PAF receptor null (Pafr-/-) mouse cerebellar granule cells.
Orsellinic acid is a benzoic acid compound shown to block PAF-mediated neuronal apoptosis.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
