BD0870232
(S)-2-((Methoxycarbonyl)amino)-3,3-dimethylbutanoic acid , 97% , 162537-11-3
Synonym(s):
(2S)-2-[(Methoxycarbonyl)amino]-3,3-dimethylbutanoic acid;N-Methoxycarbonyl-3-methyl-L -valine
CAS NO.：162537-11-3
Empirical Formula: C8H15NO4
Molecular Weight: 189.21
MDL number: MFCD07778455
EINECS: 1308068-626-2
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB24.00 | In Stock |
|
| 1g | RMB32.80 | In Stock |
|
| 5g | RMB84.00 | In Stock |
|
| 10g | RMB129.60 | In Stock |
|
| 25g | RMB234.40 | In Stock |
|
| 100g | RMB648.00 | In Stock |
|
| 500g | RMB1667.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 1090C |
| Boiling point: | 320.9±25.0 °C(Predicted) |
| Density | 1.126±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | 2-8°C |
| solubility | Soluble in ethyl acetate and methanol. |
| pka | 4.46±0.10(Predicted) |
| form | powder |
| color | White to off-white |
| Water Solubility | 26.4g/L at 20℃ |
| InChI | InChI=1S/C8H15NO4/c1-8(2,3)5(6(10)11)9-7(12)13-4/h5H,1-4H3,(H,9,12)(H,10,11)/t5-/m1/s1 |
| InChIKey | NWPRXAIYBULIEI-RXMQYKEDSA-N |
| SMILES | C(O)(=O)[C@H](C(C)(C)C)NC(OC)=O |
| LogP | 0.832 at 21℃ |
Description and Uses
The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| HS Code | 2933399090 |
